Lions Mane Mushroom


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Lion’s Mane Mushroom

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Lion’s mane mushroom may possess neuroprotective effects, suggesting benefit in neurodegenerative disease and in the management of nerve injury. Antioxidant and anti-inflammatory activities have been demonstrated. genius mushrooms However, clinical trials are lacking to support use of lion’s mane mushroom for any sign.


We have reported few clinical studies in the literature. Lion’s mane mushrooms have been consumed in traditional folk medicine and medicinal cuisine. In clinical studies evaluating effects on cognitive function, we have used the following dosages: 750 mg/day of Yamabushitake (administered as a 250 mg tablet [containing 96% Yamabushitake dry powder] 3 times a day) for 16 weeks; H.genius mushrooms erinaceus in tablet form was administered as 3 g/day for 16 weeks; and 5 g/day of the fruiting body was consumed in soup.

Benefits of Lion’s Mane 

As mentioned, lion’s mane is most recognized for its important work in supporting brain function, memory, and mood. Many studies have been conclusive that lion’s mane can assist individuals with mental focus and retaining knowledge, and even support degenerative diseases, such as Alzheimer’s disease, by stimulating nerve growth factor (NGF) (Chong et al., 2019). Nerve growth factor is a family of proteins that maintain and assist in the growth and regeneration of neurons during our adult life (Sabaratnam et al., 2013). In a 2013 study published in the International Journal of Medicinal Mushrooms, the interaction between Hericium erinaceus and NGF was studied and was found to induce the synthesis of NGF cells and promote brain neurite outgrowth activity in vitro genius mushrooms.

As humans age, certain cognitive functions start to decline, and we begin to lose our ability to form connections in the brain, learn new skills, retain information, and recall memories (Burke & Barnes, 2006). Lion’s mane is a powerful brain tonic and has increasingly been studied for its neuroprotective properties (Zhang et al., 2016). As world-renowned mycologist and author Paul Stamets says, “Lion’s mane may be our first ‘smart’ mushroom. It is a safe, edible fungus that appears to confer cognitive benefits on our aging population” (lions mane mushroom).

In a 2009 double-blind, placebo-controlled clinical trial in Japan, 50-80-year-old men with mild cognitive impairment were given four 250 mg tablets containing 96% lion’s mane powder three times a day for 16 weeks (Mori et al., 2009). The results of this study showed marked improvement on the cognitive function tests compared with the placebo group, concluding that lion’s mane may be effective in improving mild cognitive impairment in humans (Mori et al., 2009).

Lion's Mane Mushroom: What You Should Know | Herbal Academy | Lion's mane (Hericium erinaceus) mushroom is most recognized for its important work in supporting brain function, memory, and mood.

In our fast-paced society, I think most people would benefit from reduced stress and increased peace or happiness overall. Many studies are finding that consuming lion’s mane can be helpful not only for supporting brain health but also for easing anxiety and depression lions mane

Depression is a common and serious illness with broad impacts across the globe genius mushrooms. The effects of lion’s mane on brain function may also prove to be beneficial in supporting those who suffer from depression and anxiety. In a 2010 study, 30 post-menopausal women who consumed lion’s mane in a controlled dose baked into cookies over a period of 4 weeks showed less anxiety and depression and also showed improvement in mental focus . Even though there have not yet been many studies to date utilizing lion’s mane as an alternative for the treatment of depression genius mushrooms, we can be hopeful that more research will be done in this area in the future. Lion’s mane may help calm our nervous system and make us feel happier overall.

In addition to all of its cognitive and mood-enhancing benefits, lion’s mane also has significant nutritional value. Hericium erinaceus is composed of protein, carbohydrates, fiber, fats, amino acids, as well as many vitamins and minerals Lions Mane Mushrooms. Lion’s mane has also been used in Traditional Chinese Medicine as a digestive tonic for thousands of years lions mane mushroom.

As most fungi do, lion’s mane also contains a particular type of complex branched-chain polysaccharides called beta glucans. Beta glucans make lion’s mane an excellent choice for boosting immune health Lions Mane Mushrooms. In fact, the polysaccharides found in fungi are similar to the ones found in more commonly recognized immune-supporting herbs such as echinacea lions mane mushroom and astragalus (Astragalus membranaceus) Lions Mane Mushrooms. Complex polysaccharides found in herbs and mushrooms can also aid in imbalances with blood pressure, cholesterol, ulcers, cancer, diabetes, liver problems, and more (Bacha et al., 2018).

While the possibility of lion’s mane providing support for many imbalances of the body and mind is quite exciting, currently most of the research on the benefits of lion’s mane has been performed on animals. As we find more evidence that lion’s mane can help boost mental function, we can assume that more studies will be done with humans as well. Although more research stands to be done on the side effects of lion’s mane, aside from a case of reported respiratory distress linked with the consumption of lion’s mane extract (Nakatsugawa et al., 2003), it has been found to have very few side effects and is considered safe (Zhang et al., 2016). However, if you are allergic or have a sensitivity to mushrooms, avoid ingesting lion’s mane in any form.

1x per day

  • 1500 mg Lion’s Mane Mushroom
  • 250 mg Uridine
  • 2 g Fish Oil
  • 15 mg Zinc
  • 300 mg Alpha GPC
  • 500 mg Ashitaba
  • 5 mg Pregnenolone 
  • 500 mg  ALCAR
  • 500 mg L-Tyrosine

Health Benefits

Proponents claim that lion’s mane can help with a variety of health problems, including:

  • Alzheimer’s disease
  • Anxiety
  • Depression
  • High cholesterol
  • Inflammation
  • Parkinson’s disease
  • Ulcers

Lion’s Mane Mushroom Benefits

1. Enhances Brain Function

Maybe the most thoroughly researched feature of the  lion’s mane mushroom is its impact on brain cells and related functions. This incredible fungus may have revolutionary impact on neurodegenerative diseases.

One method by which lion’s mane affects brain function is by enhancing “neurite outgrowth” in the brain and related organs, according to research published in the International Journal of Medicinal Mushrooms. ( Neurite outgrowth refers to the growth of axons and dendrites from neurons (anybody’s high school biology classes coming back?genius mushrooms).

That’s a big deal in brain health research. By increasing this growth, it might be possible to slow or reverse cell degeneration in the brain — the fundamental characteristic of diseases like Alzheimer’s and Parkinson’s.

A 2012 study conducted in Malaysia found that consuming lion’s mane mushroom could actually regenerate damaged cells from peripheral nerve injury, an injury affecting the delicate tissue between your brain and spinal cord.

When studying how brain diseases might be affected by particular medications or treatments, scientists often use the PC12cell line for testing. Extracts and various forms of lion’s mane mushroom seem to have a major impact on PC12 cells, protecting them from damage and delaying their cell death significantly. This finding may prove extremely relevant for prevention or treatment of brain conditions.

In animal research published in Evidence-Based Complementary and Alternative Medicine, lion’s mane mushroom stimulates cognitive function and helps improve memory in rats, both with and without an Alzheimer’s model.  Multiple studies have found an inverse correlation between lion’s mane and Alzheimer’s-related symptoms, lions mane meaning that after consuming the mushroom extract, the rats’ symptoms improved Lions Mane Mushrooms.

An improvement of mild cognitive impairment in humans was also found in research published in Phytotherapy Research after eight to 16 weeks of lion’s mane supplementation, although this improvement did not last after subjects stopped taking this supplement. (

The danger of ischemic injury (damage caused by a lack of blood flow) to neurons is also of significance when you’re talking about brain damage and disease. In laboratory tests conducted in Taiwan, lion’s mane mushroom has been shown to help prevent this type of injury lions mane.

Taking supplements of lion’s mane has also been found to have potentially protective effects on the spread of Parkinson’s disease, another neurodegenerative disorder, according to research published in the Journal of Translational Medicine.

While this research is still in its infancy and has not progressed to large-scale human trials in most cases, the consistent effect lion’s mane mushroom has been found to have on brain cells should not be ignored.

2. May Protect Against Cancer

Lion’s mane may also be significant in treating cancer, according to a host of research. (15) In varying degrees, compounds from or supplementation with lion’s mane mushroom have been found to potentially slow the progression or reverse the spread of:

  • Leukemia
  • Gastric (stomach) cancer
  • Lung cancer
  • Cervical cancer
  • Liver cancer
  • Colon cancer
  • Breast cancer 

Regarding leukemia, lion’s mane was shown to significantly reduce leukemia cells in a Korean study.lions mane Further Korean research conducted by the Department of Molecular Science and Technology at Ajou University found that thanks to the phytochemicals in lion’s mane mushroom, it has “therapeutic potential against human leukemia.”

As far as gastric cancer is concerned, a study published in the International Journal of Biological Macromolecules found that lion’s mane caused cell death and cell cycle arrest with gastric cancer. The researchers concluded,lions mane mushroom “our study provides in vitro evidence that HEG-5 may be taken as a potential candidate for treating gastric cancer Lions Mane Mushrooms.”

Studies published in the Journal of Natural Products and Kaohsiung Journal of Medical Sciences unearth the ability of lion’s mane mushroom to treat lung cancer.  Meanwhile, according the Journal of Biomedicine and Biotechnology and the Journal of Ethnopharmacology, lion’s mane exhibits anticancer activity against colon, breast and other cancers as well.

Some studies actually suggest the use of lion’s mane mushroom supplements to treat cancer, although long-term and large-scale studies haven’t been conducted to prove that as a viable option genius mushrooms.

Another interesting finding involved the metastasis (cancer spreading) from the colon to the lung. When a cancer spreads to more than the original organ in which they found it, they consider a patient having stage IV cancer. In a study conducted on rats out of Korea, it gave rats either hot water lion’s mane extract or microwaved ethanol extracts of lion’s mane mushroom. By consuming lion’s mane extract, the rats studied showed inhibited metastasis of cancer cells to the lungs by 66 percent and 69 percent, respectively.

3. Supports Heart and Circulatory System Health

Lion’s mane mushroom might also help you in preventing heart disease. Research has found that extracts of lion’s mane can prevent the increase of LDL cholesterol (sometimes referred to as “bad” cholesterol),lions mane increase HDL, or “good,” cholesterol and lower triglycerides in the bloodstream, an early indicator of heart disease.

Stroke, a lack of blood supply to the brain from the heart, is sometimes caused by blood clots. It’s also related to atherosclerosis, a serious heart condition. An extract of lion’s mane mushroom may be able to prevent blood clots and help to reduce the risk of stroke, according to a study by from the Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences at Tohoku University in Japan.

Due in part to its powerful anti-inflammatory properties, lion’s mane mushroom might improve the function of your stomach and digestive system lions mane mushroom.

In multiple studies, lion’s mane mushroom has been shown to protect from or shrink gastric ulcers. For instance, according to a study conducted on rats by the Mushroom Research Centre at the University of Malaya in Malaysia, researchers concluded the bioactive compounds in lion’s mane extract may be responsible for the gastroprotective activity exhibited on the rats.  Research in China published in the International Journal of Medicinal Mushrooms confirms this, noting that “results indicate that the polysaccharide fraction is the active component of the H. erinaceus mycelium culture, which protects against gastric ulcers lions mane.”

Lion’s mane may also significantly improve symptoms of two major inflammatory disorders of the digestive system,lions mane mushroom gastritis and inflammatory bowel disease.

5. Reduces Inflammation

Although it’s a relatively different way of looking at health, research on natural ways to reduce inflammation is a major way natural health practitioners help prevent disease.

A 2015 study out of Japan found that lion’s mane mushroom could reduce inflammation in fatty tissue. This is important because fatty tissue inflammation is a factor in the formation of metabolic syndrome, a cluster of conditions that increase your risk of heart disease, stroke and diabetes.

Lion’s mane also has antibacterial effects against h. Pylori, often considered “the most successful pathogen in human history.” lions mane Many people never have symptoms of carrying the bacteria, but for some people it causes severe gastric conditions, like ulcers in the stomach and/or intestines Lions Mane Mushrooms.

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